What question did this study set out to answer?

This research aims to evaluate the association of normalized periprostatic adipose tissue thickness with prostate biopsy outcomes in patients classified in the double gray zone.

June 5, 2026Open Access

Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone

Key Result

Normalized periprostatic adipose tissue thickness is a novel predictor of prostate cancer in patients within the PI-RADS and PSA double gray zone.

Key Points

This research aims to evaluate the association of normalized periprostatic adipose tissue thickness with prostate biopsy outcomes in patients classified in the double gray zone.
Investigation focused on patients with PI-RADS and PSA readings in the double gray zone.
Assessment of normalized periprostatic adipose tissue thickness as a potential predictive marker.
Normalized PPAT thickness demonstrated a significant association with positive prostate biopsy outcomes, with an event rate of 21.7%.
It was proposed as a novel predictor for prostate cancer in challenging diagnostic scenarios.

Structured PICO

Does normalized PPAT thickness predict prostate cancer in patients with PI-RADS and PSA double gray zone?

Population

Patients with PI-RADS and PSA double gray zone

Intervention

Normalized periprostatic adipose tissue (PPAT) thickness measurement

Outcome

Prostate cancer (PCa) prediction/biopsy outcomes

Normalized periprostatic adipose tissue thickness may serve as a novel imaging marker to predict prostate cancer in diagnostically challenging patients.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

. 21.7%). In conclusion, we proposed normalized PPAT thickness as a novel PCa predictor in the diagnostically challenging 'double gray zone' cohort.

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