Background and Objective: Palmoplantar psoriasis (PPP) is a chronic immune-mediated inflammatory skin disorder characterized by hyperkeratotic plaques, erythema, scaling, and sterile pustules affecting the palms and soles, significantly impairing the quality of life of affected individuals. The pathogenesis of PPP involves dysregulation of inflammatory cytokines such as interleukin-17A (IL-17A) and interleukin-36 gamma (IL-36γ), which contribute to keratinocyte hyperproliferation and chronic inflammatory responses through activation of NF-κB and MAPK signaling pathways. Although conventional therapies provide symptomatic relief, prolonged treatment is frequently associated with adverse effects, recurrence, and therapeutic resistance. Siddha medicine, one of the ancient traditional systems of medicine practiced in India, describes several herbal formulations with potent anti-inflammatory and immunomodulatory properties. Among them, Sathurmuga Choornam has been traditionally used for various dermatological disorders which includes psoriasis mentioned as Kalanjagapadai. However, its molecular mechanism and pharmacological potential against Palmoplantar psoriasis remain scientifically unexplored. Therefore, the present study was designed to investigate the Molecular Docking interactions and ADME profiling of the selected phytoconstituents of Sathurmuga Choornam against major inflammatory targets associated with Palmoplantar psoriasis using computational approaches. Materials and Methods: Preliminary Molecular Docking study through computational analysis were performed with the Auto Dock tool to study the efficacy and ADME profiling was performed for Sathurmuga Choornam against Palmoplantar psoriasis. The binding action of major phytoconstituents of the drugs in Sathurmuga Choornam against various targets was documented. Results and Discussion: The selected phytoconstituents exhibited significant binding affinity and stable interactions with IL-17A and IL-36γ proteins. ADME analysis demonstrated favorable pharmacokinetic properties, acceptable bioavailability, and drug-likeness profiles, indicating potential anti-inflammatory and immunomodulatory activity against Palmoplantar psoriasis. Conclusion: The study suggests that Sathurmuga Choornam possesses promising therapeutic potential against Palmoplantar psoriasis through significant molecular interactions with inflammatory targets.
M. Santhiya*1, V. Manikandaprabu2, P. Dharani3, K. Vignesh4 (Wed,) studied this question.