Neuroprotective Effect of Low-Dose of Vitamin A on the Prefrontal Cortex of Methamphetamine Induced Adult Male Wistar Rats

Key Points

• This research aims to evaluate the neuroprotective effects of low-dose vitamin A on the prefrontal cortex affected by methamphetamine in Wistar rats.
• Adult male Wistar rats were administered methamphetamine to induce neurotoxicity.
• Low doses of vitamin A were given to assess their protective effects on the prefrontal cortex.
• Neurobehavioral assessments and histological examinations were conducted to evaluate outcomes.
• Vitamin A treatment significantly reduced neurotoxic damage in the prefrontal cortex compared to control.
• The treated group showed improved cognitive function as assessed by behavioral tests.
• Histological analysis revealed a decreased number of damaged neurons in vitamin A-treated rats.