BACKGROUND: X-rays can cause mutations in the DNA and, therefore, might lead to cancer later in life. For this reason, X-rays are classified as a carcinogen by WHO. However, the benefits of X-ray technology far outweigh the potential negative consequences of using them. Exposure of the human body to doses >1 Gy at relatively high dose rates of 0.05 Gy/h or higher results in a range of clinical syndromes known as acute radiation syndromes (ARS). PURPOSE: The study aimed to investigate the effects of single dose exposure techniques using X-rays at low dose rate (35.44 ± 7.5 μSv/hr) and high dose rate (323.66 ± 23.7 μSv/hr) on the haematological parameters have been investigated for male albino Rats. METHODS: A total of 10 groups were formed from the rats with the same biological and physiological characteristics, one of which was the control group (Group I) and the others were the experimental group (increasing time of irradiation from 10 min to 50 min for low and high irradiation doses), with those with similar body weights in the same group. Blood samples were taken from the heart directly anesthetized rats 48 hr after irradiation. Complete blood cells (CBC), and erythrocyte sedimentation rate (ESR) were determined using an automated hematology analyzer. RESULTS: The results obtained showed that the complete blood counts of the rats varied according to the time of irradiation and irradiation dose (high or low dose). Significant differences were observed between the groups in all hematologic parameters of red blood cell counts, platelets (PLTs), Hemoglobin (Hb), White Blood Cell Counts (WBCs), Lymphocyte Count (LYM) and Granulocytes (GRAN) (P < .001). While the irradiation of low and high dose regarding the time of irradiation not affect relativity. The decrease in PLT parameters in rats exposed to high dose rate radiation was 24.4% and 36.30% for low and high single irradiation dose, respectively. CONCLUSION: The study found that in vivo exposure of male rats to low and high doses of exposure has a relatively significant impact on haematological parameters. The duration of exposure to X-ray radiation is the most important factor in determining the biological risks associated with X-ray expo. The time of exposure had more effects on complete blood cells rather than erythrocyte sedimentation rate.
Abdulla et al. (Sun,) studied this question.