Abstract Introduction The aim of this study was to evaluate outcomes of surgical correction of penile curvature using autologous graft materials in patients with Peyronie’s disease, with emphasis on functional recovery, penile length changes, cosmetic results and patient-reported satisfaction. Due to unavailability of commercial extracellular matrix grafts, autologous materials including buccal mucosa, rectus fascia, fascia of the tensor fasciae latae and saphenous vein were utilized. Objective This study included male patients treated for penile curvature due to Peyronie’s disease at the Department of Urology, Clinical Centre University of Sarajevo between 2018 and 2023. All patients had stable disease for more than 12 months. Methods Preoperative assessment included penile Doppler ultrasonography, curvature measurement and flaccid penile length evaluation. Erectile function was measured using the validated International Index of Erectile Function (IIEF-5), and disease burden was assessed via the Peyronie’s Disease Questionnaire (PDQ). A postoperative patient satisfaction survey was performed combining validated components (Erection Hardness Score and EDITS satisfaction elements) with a graft-specific preference scale. Patients were divided into four groups based on graft type. Results Groups 3 and 4 demonstrated superior functional and cosmetic outcomes following surgery (p0.05). There were no significant differences in complication rates among groups (p0.05). Curvature recurrence was more frequently observed in Group 4, although not statistically significant (p0.05). Penile shortening occurred more often in Groups 1 and 2 (p0.05). Improvement in postoperative IIEF-5 scores was most pronounced in Groups 3 and 4. The patient satisfaction survey showed that patients reported higher postoperative satisfaction, better perceived length preservation, and greater overall acceptability when buccal mucosa was used as graft material compared to other autologous grafts. Conclusions In settings where commercial grafts are unavailable, autologous graft materials represent a viable option for surgical correction of Peyronie-related curvature. Based on postoperative functional outcomes and validated patient satisfaction measures, buccal mucosa and saphenous vein grafts demonstrated the most favorable profiles and should be considered preferred autologous grafting options. Disclosure No
Bajramovic et al. (Mon,) studied this question.