Lower estimated glucose disposal rate (1st vs 3rd tertile) was significantly associated with elevated cardiovascular disease risk in patients with type 2 diabetes (OR 2.33; 95% CI 1.67-3.26).
Observational (n=1,525)
Is lower estimated glucose disposal rate (eGDR) associated with increased cardiovascular disease risk in patients with type 2 diabetes?
Lower estimated glucose disposal rate is independently associated with an increased prevalence of cardiovascular disease in patients with type 2 diabetes, suggesting its potential utility as a risk marker.
Odds Ratio: 2.33 (95% CI 1.67–3.26)
p-value: p=<0.05
Introduction and Objective: The estimated glucose disposal rate (eGDR) is known as a surrogate marker of insulin resistance (IR) and suggested to be associated with the risk of cardiovascular disease (CVD) and mortality. We examined whether eGDR was associated with CVD risk in patients with type 2 diabetes (T2DM). Methods: A total of 1,525 patients with T2DM were involved in this study and divided into 3 groups according to the tertile of sex-specific eGDR. CVD was defied as having coronary heart disease (CHD), ischemic stroke (IS), and/or peripheral artery disease (PAD). Results: Patients with CVD were more likely to be old and male and have hypertension. They had higher diabetes duration (DD), waist circumference (WC), and serum creatinine (Cr), but lower diastolic blood pressure (DBP), HDL cholesterol, estimated glomerular filtration rate (eGFR), and eGDR than those without CVD. Subjects in the 1st tertile eGDR group was older and had higher DD, WC, body mass index (BMI), systolic BP (SBP), C-reactive protein (CRP), triglycerides (TG), fasting blood glucose (FBS), HOMA-IR, HbA1c, and Cr, but lower HDL cholesterol and eGFR than those in the 3rd tertile group. CVD and CHD, and PAD prevalence were gradually increased with decreasing tertile of eGDR (p 0.05). After adjusted for age and sex, the odds ratios (ORs) and 95% confidence intervals (CIs) for CVD, CHD, IS, and PAD were 2.01 (1.43−2.81), 1.72 (1.17−2.52), 1.62 (0.95−2.77), and 1.39 (0.60−3.23) in the 2nd tertile group and 2.33 (1.67−3.26) 2.24 (1.54−3.27), 1.45 (0.84−2.49), and 2.38 (1.09−5.21) in the 1st tertile group. After further adjusting for BMI, SBP, DD, CRP, FBS, TG, HDL cholesterol, FBS, eGFR, and HOMA-IR, the ORs and 95% CIs for CVD and CHD remain significant in the 2nd and 1st tertile groups. Conclusion: Lower eGDR was significantly associated with elevated CVD and CHD risk independently of multiple potential confounders. Our findings proposed that measuring eGDR may be a noble marker for documenting CVD risk in patients with T2DM. Disclosure J. Shin: None.
Jang Yel Shin (Fri,) conducted a observational in Type 2 diabetes (n=1,525). Lower estimated glucose disposal rate (1st tertile) vs. Higher estimated glucose disposal rate (3rd tertile) was evaluated on Cardiovascular disease (coronary heart disease, ischemic stroke, and/or peripheral artery disease) (OR 2.33, 95% CI 1.67-3.26, p=<0.05). Lower estimated glucose disposal rate (1st vs 3rd tertile) was significantly associated with elevated cardiovascular disease risk in patients with type 2 diabetes (OR 2.33; 95% CI 1.67-3.26).