2209-P: Clinical and Metabolic Profiles of 55,464 Newly Diagnosed Type 2 Diabetes Patients in Mexico: Real-World Evidence from the National Chronic Disease Information System (SIC)

Introduction and Objective: In Mexico, a substantial proportion of T2D cases are detected in PHC settings, highlighting the critical role of frontline health services for early diagnosis and disease surveillance. The objective of this study was to characterize the clinical and metabolic profiles of newly diagnosed T2D patients in PHC units. Methods: We conducted an observational, descriptive, cross-sectional study using data from the national Chronic Disease Information System (SIC). The analysis included information from 7,980 PHC units registered between January 2022 and November 2025. Patients were stratified according to their HbA1c levels. Demographic, clinical, and metabolic variables were compared using χ² tests. Results: A total of 55,464 newly diagnosed T2D cases were included into the analysis. The study population was predominantly female (67.73%), with the highest proportion of cases observed among individuals aged 45-59 years (45.35%). Cardiometabolic comorbidities were highly prevalent, including overweight (35.67%), obesity (47.31%), hypertension (27.40%), dyslipidemia (73.6%), and CKD (7.43%). At diagnosis, 24.1% of the patients had HbA1c 7%, whereas 75.9% had HbA1c ≥7%. Diabetes-related complications were more frequent among patients with higher HbA1c and were most prevalent in those with HbA1c ≥12%. Despite severe hyperglycemia, the most frequent initial pharmacological treatment was metformin in monotherapy (43.43%), even when HbA1c ≥12% (26.51%). Conclusion: In Mexico, most newly diagnosed T2D patients have complex clinical and metabolic profiles with a high burden of cardiometabolic comorbidities, and an increasing frequency of diabetes-related complications, indicating advanced disease progression that underscores the urgent need for systematic screening strategies that go beyond PHC units, and comprehensive disease management within them. Disclosure D. Alvarez-Hernandez: None. G. Martinez-Silva: None. A.A. Montoya: None. R. Garcia-Cerde: None. R. Saucedo-Martinez: None. H.J. Gallardo-Rincon: None. R. Mujica-Rosales: None. R. Tapia-Conyer: None.