Introduction and Objective: Chronic low-grade inflammation contributes to the pathogenesis and complications of type 1 diabetes mellitus (T1DM). IL-6 and IL-4 regulate immune responses and may reflect disease activity. This study assessed associations between IL-6, IL-4, and clinical parameters in T1DM, particularly disease duration and body mass index (BMI). Methods: A cross-sectional correlation analysis was performed in a T1DM cohort. Serum IL-6 and IL-4 levels were measured and correlated with disease duration and BMI using Spearman’s rank test. Results: IL-6 levels showed a significant inverse correlation with T1DM duration (r = −0.452; p 0.05), suggesting reduced acute inflammatory activity over time, possibly due to immune regulation, cell exhaustion, and transition to a chronic inflammatory state. IL-4 was inversely correlated with BMI (r = −0.419; p 0.05), indicating suppressed Th2 activity in individuals with higher BMI, favoring a Th1-dominant, pro-inflammatory profile linked to insulin resistance and complications.s. Conclusion: IL-6 and IL-4 demonstrate distinct inverse correlations with disease duration and BMI in T1DM, respectively. These findings suggest their potential utility as immunoinflammatory biomarkers for metabolic and vascular risk assessment. Disclosure A. Sokolova: None.
A.M. Sokolova (Fri,) studied this question.