The presence of impaired fasting glucose (≥100mg/dL) across 1h-OGTT categories was associated with a higher prevalence of insulin resistance and MASLD (P<0.05).
Cross-Sectional (n=1,259)
Yes
Does combining fasting glucose assessment with the 1-hour OGTT improve cardiometabolic risk stratification in screening populations?
Adding fasting glucose assessment to the 1-hour OGTT improves the identification of patients at higher cardiometabolic risk across different ethnic groups.
p-value: p=<0.05
Introduction and Objective: The OGTT reveals both glucose tolerance and cardiometabolic risk. Interpretation of the 2h-OGTT is based on both fasting and 2h glucose. The 1h-OGTT, currently under development by the International Diabetes Federation (IDF), focuses exclusively on 1h glucose. Our goal was to determine if cardiometabolic risk detection by the 1h-OGTT was improved by including assessment of the presence of impaired plasma glucose (IFG) ≥100mg/dL. Methods: Two populations were evaluated, African descent and South Asians. The African descent population were healthy African Americans and African immigrants in America seeking health screening (n=712, age: 40±12y (mean±SD), BMI: 27.9±4.6, range 18.8 - 46.2 kg/m2) The South Asians were clinic attendees in Chennai, India who came for preventive health checkups (n=545, age: 51±15y, BMI: 27.4±5.7, range 17.4 - 47.2 kg/m2). Glucose tolerance status was determined by the 1h-OGTT using IDF criteria for 1h-glucose: normal glucose tolerance (NGT) 155 mg/dL, intermediate hyperglycemia (IH), 155 - 208 mg/dL, and DM ≥209 mg/dL. Each glucose tolerance category was sub-divided by presence or absence of IFG. Cardiometabolic risk factors evaluated were: insulin resistance (IR) determined by HOMA-IR, lipids (TG, LDL, TG/HDL, LDL/HDL), MASLD and eGFR. Results: In the African descent cohort, the prevalence of NGT, IH and DM were: 58% (413/712), 34% (242/712), and 8% (57/712), resp. and for South Asians were: 28% (154/547), 27% (150/547), and 45% (243/547), resp. In the African descent cohort, in all three glucose tolerance categories, IR and MASLD prevalence were higher in the presence of IFG (all P0.05). In the NGT category, lipids were higher in the group with IFG (all P0.01). In South Asians, the presence of IFG in the NGT group was associated with a higher prevalence of MASLD and lower eGFR (both P0.01). Conclusion: Cardiometabolic risk was higher in the presence of IFG. Including assessment of fasting glucose when 1h-OGTT are performed enhances cardiometabolic risk stratification. Disclosure P. Thyparambil Aravindakshan: None. A. Bharadwaj: None. A. Shah: None. R. Anjana: None. G. Smith: None. C. DuBose: None. D.B. Sacks: Other - Crada; Current; Sebia. V. Mohan: None. A. Sumner: None.
ARAVINDAKSHAN et al. (Fri,) conducted a cross-sectional in Cardiometabolic risk (n=1,259). Impaired fasting glucose (IFG) ≥100mg/dL vs. Absence of IFG was evaluated on Cardiometabolic risk factors including insulin resistance, lipids, MASLD, and eGFR (p=<0.05). The presence of impaired fasting glucose (≥100mg/dL) across 1h-OGTT categories was associated with a higher prevalence of insulin resistance and MASLD (P<0.05).