What question did this study set out to answer?

The objective is to evaluate the adherence to guideline-directed medical therapies for cardiovascular and kidney risks in patients with type 2 diabetes.

June 7, 2026

2023-P: From Guidelines to Practice: System-Level Adherence to Guideline-Directed Diabetes Therapies in Real-World Academic Practice

Key Points

The objective is to evaluate the adherence to guideline-directed medical therapies for cardiovascular and kidney risks in patients with type 2 diabetes.
Leveraged a multi-disciplinary initiative at a tertiary academic health care center.
Assessed current prescriptions of key guideline-directed medical therapies in a population of 89,907 adults with type 2 diabetes.
In patients with established cardiovascular disease, only 58% were prescribed a statin, 50% an ACEi/ARB, and 11% a GLP-1 RA.
Among those with chronic kidney disease, 14% received a SGLT2i, 11% a GLP-1 RA, and 9% the combination.
Only 28% of individuals with both cardiovascular disease and chronic kidney disease were prescribed a GLP-1 RA or SGLT2i.

Abstract

Introduction and Objective: Despite high prevalence of cardio-kidney-metabolic (CKM) burden in type 2 diabetes (T2D) and the ADA Standards of Care (SOC) recommending guidelines-directed medical therapies (GDMT) for CKM risk reduction, GDMT remain highly underused Methods: We leveraged a large tertiary academic health care center and a multi-disciplinary collaboration initiative to assess current practices and optimize diabetes care delivery across the entire health system. Main outcomes were current prescriptions of any of the following key GDMT: high-intensity statin, angiotensin-converting enzyme inhibitor (ACEi)/angiotensin-receptor blocker (ARB), sodium glucose co-transporter-2 inhibitors (SGLT-2i), glucagon-like peptide-1 receptor agonist (GLP-1RA). Results: Among 89,907 contemporary T2D adults (mean age 67 years, 50% female, 16% Hispanic/Black), 40% had established cardiovascular disease (CVD) 25% established atherosclerotic CVD (ASCVD),14.0% symptomatic heart failure (HF), and 18 % had chronic kidney disease (CKD).Among T2D and established ASCVD, symptomatic HF or CKD, only 58%, 50% and 43% were prescribed a statin, and 35%, 36% and 37% were prescribed an ACEi/ARB respectively. Among those with established ASCVD only 11%,15% and 9% were prescribed a GLP-1 RA, SGLT2i or GLP-1 RA/SGLT2i combination, among those with HF only 10%, 22% and 11% were prescribed a GLP-1 RA, a SGLT2i or GLP-1 RA/SGLT2i, and among those with CKD, only 14% received a SGLT2i, 11% a GLP1-RA, and 9% combination respectively. Although 50% T2D individuals with CVD also had CKD-the highest-risk phenotype, only 28% were prescribed a GLP-1RA or SGLT2i. Conclusion: These real live data reveal substantial system-wide gaps in the use of GDMT and evidence-based care for T2D and established CKM. To address these gaps, we are implementing standardized, multifaceted, and workflow-integrated interventions aligned with the ADA SOC across the entire health system and reassess these metrics at 6 Current; Organon. R. Hasan: None. R. Pop-Busui: Board Member; Current; American Diabetes Association. Consultant; Current; Averitas Pharma, Inc. Research Support; Current; Bayer AG. Consultant; Current; Lexicon Pharmaceuticals, Inc. Research Support; Current; National Institutes of Health. Consultant; Current; Novo Nordisk, Roche Diagnostics, Vertex Pharmaceuticals Incorporated. Consultant; Ended; Viatris Inc.

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