Abstract: CONTEXT: Platelet transfusion is vital for managing thrombocytopenia, especially in patients with hematological malignancies, anemia, chronic diseases, and postsurgical complications. AIMS: This study aimed to compare the effectiveness of random donor platelets (RDPs) and single donor platelets (SDPs) using corrected count increment (CCI) and percent platelet recovery (PPR) as key parameters. SETTINGS AND DESIGN: A prospective comparative study was conducted in the Department of Immunohematology and Blood Transfusion at Government Medical College, Jammu, over 1 year (August 2023–July 2024). SUBJECTS AND METHODS: Sixty platelet transfusions (30 RDP, 30 SDP) were analyzed. Pre- and post-transfusion platelet counts were recorded at 1 and 24 h, and CCI and PPR were calculated. STATISTICAL ANALYSIS USED: Statistical significance was assessed using a t -test with P < 0.05 considered significant. RESULTS: The mean platelet increment at 1 h was 21,190 ± 4636.57/μL for RDP and 23,236.67 ± 4453.39/μL for SDP ( P = 0.86). At 24 h, the increment dropped to 10,950 ± 3290.71/μL (RDP) and 11,703.33 ± 3148.01/μL (SDP) ( P = 0.369). The mean 1-h CCI was 9219.88 ± 2950.74 for RDP and 10,079.60 ± 2740.26 for SDP ( P = 0.247), which declined at 24 h to 4935.23 ± 1633.56 (RDP) and 5062.37 ± 1608.93 (SDP) ( P = 0.762). The 1-h PPR was 24.09% ± 6.29% (RDP) versus 25.17% ± 7.43% (SDP) ( P = 0.547), which dropped at 24 h to 12.47% ± 4.24% (RDP) and 12.65% ± 4.31% (SDP) ( P = 0.888). CONCLUSIONS: RDP and SDP transfusions demonstrated comparable efficacy in terms of platelet increment and recovery. Despite slightly higher responses with SDP, the differences were not statistically significant.
Gorka et al. (Tue,) studied this question.