We present a semi-analytic model (SAM) of galaxy formation derived entirely from the One- Octonion Brane-Bulk Framework, with zero free parameters. The model replaces the calibrated subgrid prescriptions of state-of-the-art hydrodynamical simulations such as COLIBRE (Schaye et al. 2026, MNRAS 548) with analytically derived physics: (1) star formation threshold Σcrit (z) = a₀ (z) /2πG, evolving from 124 M /pc² at z=0 to 1556 M /pc² at z=7; (2) AGN feedback efficiency ☉ ☉ η = 6/49 = 12. 24%, derived from G₂ jet topology; (3) galaxy half-mass radius r = √ (GM /a₀ (z) ), ★ derived from the T2* coherence radius; and (4) sump self-quenching at M crit = 10¹0. 54 M, ★ ☉ where rT2* (MBH) = hISM. We augment the standard SAM with primordial G₂ vortex initial conditions (Paper CLVII): topological defects from the pre-QCD negative-temperature epoch that bypass the Freeman star-formation threshold, produce compact early galaxies (Little Red Dots), and provide spin seeds for overmassive early black holes, with a fixed density nᵥortex ~ (δM/M) ² × nKibble ~ 2. 2×10 ⁷ Mpc ³. We identify six lensing confounds that systematically bias the ⁻ ⁻ calibration targets of COLIBRE and analogous simulations: sump isothermal-sheet convergence (κ ∝ 1/R vs NFW κ 1/R^ (4/3) ), sump-evolution distance shifts (Δχ/χ ~ −1. 2% at z=2), magnification ∝ bias inflating the z>4 GSMF by 0. 3–0. 6 dex, vortex topology lensing, early galaxy compactness, and AGN overcalibration. The framework SAM recovers MW-type sizes (3. 5 kpc), massive galaxy sizes (11 kpc), and the GSMF turnover (10¹0. 54 M) without any simulation runs or emulator training. ☉ Part of the One-Octonion Brane-Bulk Framework series. Anchor DOI: 10. 5281/zenodo. 19120873. Community: one-octonion-brane-bulk. Author: Bharathi Dasan Jagadeesan, M. D. , University of Minnesota. ORCID: 0000-0002-1143-941X.
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