Type 2 diabetes was associated with a significantly higher prevalence of liver and/or pancreatic fibro-inflammation compared to matched controls without T2D (49% vs 16%, p<0.001).
Observational (n=634)
Blinded analysis
Yes
Is multiorgan fibroinflammation more prevalent in individuals with Type 2 Diabetes compared to those without?
Approximately half of individuals with Type 2 Diabetes have liver or pancreatic fibro-inflammation detectable by non-invasive MRI, a significantly higher prevalence than in matched controls.
Absolute Event Rate: 49% vs 16%
p-value: p=<0.001
Introduction and Objective: We investigated the prevalence of organ impairment in people with T2D in primary care. Methods: People living with T2D and no prior heart disease were recruited from 5 sites and underwent standardised MRI (CoverScan) to measure fat (visceral, subcutaneous, epicardial, pericardial, hepatic, pancreatic), inflammation (hepatic, pancreatic, renal), muscle volume (myocardial, skeletal) and cardiac function. Comparisons were made to matched controls without T2D based on age, sex, ethnicity, BMI and waist circumference (WC) from UK Biobank, and self-reported healthy volunteers with no known disease (HV). Clinical obesity defined as Lancet Commission: high WC 0.001). Steatosis was at similar levels with or without T2D (Figure). Conclusion: Approximately half of people living with T2D have liver or pancreatic fibro-inflammation, which can be diagnosed non-invasively and should be prioritised for clinical trials and treatment. Disclosure C. Diamond: Employee; Current; Perspectum. L.F. Cardiel Castro: None. R.J. Suriano: Employee; Current; Perspectum. T. Jeevaratnam: None. H.B. Thomaides Brears: Employee; Current; Perspectum Ltd. Stock/Shareholder; Current; Perspectum Ltd. S. Rymell: Employee; Current; Perspectum. K. Zarbalian: None. A. Rajarajan: Research Support; Current; Perspectum. I. Yeung: None. R.D. Hamilton: None. R. Pattanshetty: Employee; Current; Perspectum Diagnostics, perspectum diagnsotics. Funding UK Biobank accessed under application 9914
DIAMOND et al. (Sat,) conducted a observational in Type 2 Diabetes (n=634). Type 2 Diabetes vs. Matched controls without T2D and healthy volunteers was evaluated on Fibro-inflammation in the liver and/or pancreas (p=<0.001). Type 2 diabetes was associated with a significantly higher prevalence of liver and/or pancreatic fibro-inflammation compared to matched controls without T2D (49% vs 16%, p<0.001).