Real-world genomic profiling of solid tumors: validation and clinical insights from a Brazilian cohort

Key Points

• The study aims to validate the TSO500 assay for genomic profiling of solid tumors and assess its clinical relevance in cancer management.
• Validation of the TSO500 assay in a CAP-accredited Brazilian laboratory.
• Analysis of Comprehensive Genomic Profiling results from 454 patients with cancer.
• Evaluation of analytical performance and identification of genomic alterations.
• The TSO500 assay demonstrated high analytical performance.
• Key genomic alterations, including novel fusions, were identified in the patient cohort.
• Findings support the implementation of precision-guided cancer management strategies.