Abstract- Oral Dissolving Film (ODFs) are thin , flexible strips that dissolve in mouth without the need forwater. They were developed to overcome swallowing difficulties associated with tablets and capsules, especially inchildren, elderly patients, and individuals with dysphagia. These films disintegrate rapidly in saliva and provide fastdrug release, leading to quicker onset of action. In some cases, drug absorption through the oral mucosa can partiallyavoid first pass metabolism, thereby improving bioavailability. This review discusses the structure and physiology ofthe buccal cavity, factors affecting buccal drug absorption, classification of oral dissolving films, formulationcomponents, and different preparation methods such as solvent casting and hot-melt extrusion etc. It also explainsimportant evaluation parameters, packaging consideration, and marketed products. Although oral dissolving filmshave some limitation, such as moisture sensitivity and limited drug loading capacity they offer many advantagesincluding improved patient compliance, accurate dosing, conveniences, and enhanced therapeutic effectiveness.Therefore, ODFs are considered a promising and innovative drug delivery system in modern pharmaceutical science.
Chakravarthi K S S, Ilango K B, Brindha E, Jeevitha T, Kanishhari J, Thavaseelan N, Kannan R (Wed,) studied this question.