Among 783,801 adolescents and young adults, the overall prevalence of T1D and T2D was 4.32 and 6.56 per 1,000 respectively, with T2D showing an early and progressive rise across age groups.
Observational (n=783,801)
In a diverse cohort of adolescents and young adults, the prevalence of type 2 diabetes progressively rises and overtakes type 1 diabetes, with this shift occurring earlier in non-White populations.
Introduction and Objective: The growing burden of type 2 diabetes (T2D) in adolescents and young adults (AYAs) has highlighted changing diabetes patterns at younger ages. We determined changes in prevalence of type 1 diabetes (T1D) and T2D across the adolescent and young adult ages and examined differences across racial and ethnic groups. Methods: We analyzed 2024 electronic health record data from 783,801 AYAs aged 10-30 years with prevalent diabetes from Kaiser Permanente Northern California as part of the Predictors of Adverse Cardiometabolic Problems in Adolescents and Young Adults (PAPAYA) Study. Diabetes type was classified using a validated algorithm. We calculated the proportion of T1D and T2D cases by age and race/ethnicity across four age categories (10-15, 16-20, 21-25 and 26-30). Results: The prevalence of T1D and T2D among KPNC members aged 10-30 years was 4.32 and 6.56/1,000 respectively. Overall, T1D was more common than T2D (3.28 vs 1.04/1000) in early adolescence, but T2D increased steadily with age, becoming the more common type by ages 21-25 (T1D: 6.67 vs T2D: 4.97/1000) (Fig 1a). Earlier T2D predominance was evident in all non-White groups (Fig 1b-1i). Conclusion: In this diverse, real-world cohort, we observed an early and progressive relative rise in T2D that differed markedly by race and ethnicity. These findings underscore the need for screening and clinical strategies that reflect this shifting epidemiology. Disclosure S. Srinivasan: Research Support; Current; Abbott, Eli Lilly and Company. A. Karter: Research Support; Current; Dexcom, Inc. J.Y. Liu: None. C.J. Huang: None. J. Acker: None. S. Daredia: None. J. Deardorff: None. S. Negriff: None. A. Kanaya: None. A. Kubo: None. Funding National Institutes of Health (R01DK139116)
Srinivasan et al. (Fri,) conducted a observational in Type 1 and Type 2 Diabetes (n=783,801). Age and race/ethnicity was evaluated on Proportion of T1D and T2D cases by age and race/ethnicity. Among 783,801 adolescents and young adults, the overall prevalence of T1D and T2D was 4.32 and 6.56 per 1,000 respectively, with T2D showing an early and progressive rise across age groups.