ABSTRACT Background Melasma is a common hyperpigmentation disorder primarily affecting women, influenced by ultraviolet exposure, hormones, and genetics. Kligman's formula is a first‐line therapy, but emerging evidence suggests that topical metformin, an antidiabetic with antimelanogenic effects, may enhance treatment outcomes. The objective of this study is to compare the efficacy and safety of Kligman's formula with and without 30% topical metformin in bilateral facial melasma. Methods In this randomized, double‐blind, split‐face clinical trial, 31 patients with symmetrical facial melasma applied Cream A (Kligman's formula + 30% metformin) to one side and Cream B (Kligman's formula alone) to the other for 2 months. Outcomes included MASI scores, repigmentation grading, patient satisfaction via Visual Analog Scale (VAS), and side effect profiles assessed at baseline, post‐treatment, and 2 months after discontinuation. Results Both treatments significantly reduced pigmentation and improved homogeneity. Cream B showed a slightly greater reduction in darkness, while Cream A led to more stable repigmentation and fewer cases of post‐inflammatory hyperpigmentation. No significant differences were found between post‐treatment and follow‐up scores. VAS scores indicated high patient satisfaction across both groups. Conclusion Adding 30% topical metformin to Kligman's formula is safe and comparably effective in melasma treatment, offering potential benefits in pigment stability and reduced PIH. Although differences were not statistically significant, clinical trends support further investigation through larger, long‐term studies. Trial Registration ClinicalTrials.gov identifier: IRCT20150706023081N2
Iraji et al. (Mon,) studied this question.