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This review aims to clarify the pathophysiology of polycystic ovary syndrome and its health implications.

June 17, 2026Open Access

Polyendocrine metabolic ovarian syndrome (PMOS)/polycystic ovary syndrome (PCOS): current and future trends

Key Points

This review aims to clarify the pathophysiology of polycystic ovary syndrome and its health implications.
Reviewed existing literature on PCOS, focusing on pathophysiology, diagnostic criteria, and management strategies.
Examined health sequelae and future directions for research.
Highlighted gaps in understanding the pathophysiology of PCOS.
Outlined current diagnostic criteria and management approaches.
Emphasized the need for further research in poorly understood areas.

Abstract

Polycystic ovary syndrome (PCOS), also known as polyendocrine metabolic ovarian syndrome (PMOS), is the most common endocrinologic disorder to affect women. Despite this, the pathophysiology of the disease is not entirely known. This has hindered the diagnosis of the disease and appropriate treatment for millions of individuals. In this Review, we discuss the proposed pathophysiology of PCOS from a translational perspective. We review the existing diagnostic criteria of PCOS and current management strategies. Finally, we discuss the long-term health sequelae associated with PCOS, future directions, and areas of needed research in this often-overlooked disease.

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