Background and aim: Plaque-related pathological conditions such as peri-implantitis (PI) affect the tissues surrounding dental implants and affect the survival of implants. Hence, treatment of PI is of great importance, but bacterial resistance has been observed with antibiotics. Hence, the use of nanoparticles has been proposed. The present study aimed to evaluate the effect of metal nanoparticles (silver nanoparticles) in the treatment of peri-implantitis.Material and methods: The international databases PubMed, EMBASE, and Web of Science were searched using keywords aligned with the study objective up to July 2025. Two blinded, independent authors reviewed all articles. STATA/MP. v17 (College Station, Texas, USA) was used to perform the analyses.Results: In the present study, fifteen in vitro studies were included. Antibacterial activity of AgNPs in dental implants was 60% (ES: 0.60; 95% CI, 0.54, 0.67). The effectiveness of AgNPs for the treatment of peri-implantitis was 73% (ES: 0.73; 95% CI, 0.66, 0.81).Conclusions: The present study showed acceptable effectiveness of silver nanoparticles' antibacterial activity and reduction of inflammatory factors in the treatment of PI.
Firouzi et al. (Mon,) studied this question.