ABSTRACT This study reports, for the first time, the phytochemical characterization and biological evaluation of the essential oils (EOs) and solvent extracts of Alkanna strigosa collected from Jordan. Gas chromatography–mass spectrometry (GC–MS) analysis of the fresh and air‐dried plant's EOs led to the identification of 38 and 32 constituents, representing 98.13% and 97.45% of the total compositions, respectively. Oxygenated sesquiterpenes were the predominant class in both oils (34.25% and 60.66%). The EOs exhibited strong antioxidant activity, with low IC 50 values in DPPH (5.79 and 10.0 µg/mL) and ABTS (1.18 and 1.15 µg/mL) assays for FEO and DEO, respectively. Soxhlet extraction using solvents of increasing polarity afforded ethyl acetate (ASE), acetone (ASA), and methanol (ASM) extracts. LC–MS/MS profiling revealed a high abundance of phenolic compounds and flavone glycosides, particularly in the ASM extract, which showed notable antioxidant activity. All extracts exhibited weak acetylcholinesterase inhibitory effects and lacked significant antibacterial activity against selected Gram‐positive and Gram‐negative bacteria. Furthermore, no relevant cytotoxic effects were observed against cancerous or normal cell lines. These findings highlight A. strigosa as a promising natural source of antioxidant and neuroprotective compounds.
Al‐Qudah et al. (Mon,) studied this question.