High Resolution Image Download MS PowerPoint Slide Curcuminoids possess potent anti-inflammatory and antioxidant properties but suffer from poor aqueous solubility and rapid gastric degradation, limiting their therapeutic efficacy. This study developed turmeric curcuminoid-loaded nanostructured lipid carriers (TUR-NLCs) with chitosan-gum Arabic (CS-GA) polyelectrolyte complex coatings to enhance gastrointestinal stability and controlled oral delivery. TUR-NLCs were prepared via hot emulsification-microfluidization using optimized medium-chain triglyceride (MCT) and glycerol monostearate (GMS) ratios, followed by coating with a preformed CS-GA polyelectrolyte complex. The nanocarriers were comprehensively characterized for physicochemical properties, drug release kinetics, gastrointestinal stability, and biological activity. The optimized formulation (6MCT/3GMS) achieved a particle size of 53.20 ± 2.1 nm with 68.04 ± 0.98% encapsulation efficiency. Solid-state characterization indicated an amorphous or noncrystalline state of curcuminoids within the lipid matrix. The CS-GA coating significantly enhanced stability under simulated gastric conditions (pH 1.2), with controlled intestinal release following Fickian diffusion mechanisms (Korsmeyer–Peppas model, R 2 > 0.94, n = 0.304–0.336). The nanocarriers demonstrated good in vitro safety in RAW 264.7 macrophages (IC 50 > 1000 μg/mL) while preserving anti-inflammatory activity (up to 25.91% NO inhibition at 100 μg/mL). This formulation development study demonstrates that CS-GA-coated NLCs provide enhanced gastrointestinal stability and controlled release characteristics, establishing proof of concept for the coating strategy. In vivo studies are warranted to validate therapeutic potential.
Yarovaya et al. (Fri,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: