What question did this study set out to answer?

This research aims to revise the RNA-DNA transition model based on new biochemical constraints and propose a more accurate evolutionary path.

June 21, 2026Open Access

Dancing Bubbles Model v2.0 — The RNA-DNA Continuum Hypothesis: Geochemical, Molecular, and Thermodynamic Origins of the RNA-to-DNA Evolutionary Transition in Hadean Hydrothermal Pores

Key Points

This research aims to revise the RNA-DNA transition model based on new biochemical constraints and propose a more accurate evolutionary path.
Introduced the Dancing Bubbles model v2.0 to explain RNA-to-DNA transition.
Outlined a three-stage molecular transition involving nucleotide world, RNA self-replication, and conversion to DNA.
Formulated seven falsifiable predictions based on the revised model.
Revised the DNA-first assumption, highlighting RNA's biochemical precedence with a ribosomal RNA core.
Increased LUCA compatibility features from 5/8 to 8/8.
Provided seven new falsifiable predictions to support the proposed model.

Abstract

This paper presents v2.0 of the Dancing Bubbles model, introducing the RNA-DNA Continuum Hypothesis. The DNA-first assumption of v1.0 is revised based on biochemical constraints: the ribosomal RNA catalytic core establishes RNA as biochemically prior to DNA. A three-stage molecular transition is proposed: (I) Pre-RNA nucleotide world, (II) RNA self-replication and ribozyme activity, (III) RNA-to-DNA conversion driven by FeS2 radical chemistry. LUCA compatibility increases from 5/8 to 8/8 features. Seven revised falsifiable predictions are formulated.

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