This paper establishes the core foundational definition of the intrinsic fixed G₀ architecture for all human somatic cells, forming the basic axiom of the entire SFL-CELL serial. All cell types carry an unchangeable initial functional framework G₀ formed during developmental differentiation; no cell can spontaneously reconstruct new core functional modules or evolve alternative native structures. Any functional decline, tissue lesion or pathological phenotype originates from cumulative structural damage denoted as ΔGd, which continuously erodes the intact state of the original G₀ framework rather than rewriting its core design. This article standardizes unified mathematical expression for cellular structural loss, defines core variables consistent with SFL-VIR and SFL-EAI series, and distinguishes physiological minor wear from pathological irreversible ΔGd accumulation. The established G₀−ΔGd cellular framework provides a shared analytical basis for subsequent discussions of SLE, malignant proliferation, neuronal collapse and degenerative protein disorders in follow-up CELL papers. Universal state equation shared across all SFL subsystems G = G₀ + ΔGd(+) − ΔGd(−) This paper clarifies that G₀ represents the complete, undamaged baseline function of a cell, ΔGd(+) refers to reversible minor physiological abrasion, and ΔGd(−) stands for permanent structural impairment that cannot be fully restored through routine metabolic repair. When the net accumulation of ΔGd(−) exceeds the self-repair threshold of the cell's inherent framework, persistent functional deficiency emerges, laying the unified theoretical foundation for all chronic cellular pathologies covered in SFL-CELL-02 to SFL-CELL-06.
FOO SENG ANG (Sat,) studied this question.