This paper reinterprets the pathological characteristics of systemic lupus erythematosus (SLE) under the quantitative lifespan framework of SFL-LS, fully consistent with the platelet repair dysfunction mechanism demonstrated in SFL-CELL-02. This paper reinterprets the traditional autoimmune framework, proposing that autoantibody production is a secondary response to chronic cellular debris accumulation, rather than the primary pathological event. The root driver of SLE is irreversible ΔGd(-) damage to the G₀ repair module of bone marrow hematopoietic stem cells, which generates defective platelets incapable of repairing systemic microvascular lesions. Persistent unresolved microdamage leads to widespread premature cell breakdown, drastically lowering the whole-body average functional cycle Tavg and accelerating consumption of the fixed lifetime renewal quota N. Adopting the unified baseline standard N=10 for all serial numerical cases: healthy subjects with intact bone marrow function maintain Tavg = 8 years, corresponding to a theoretical lifespan of 80 years. In SLE patients with damaged platelet repair modules, systemic continuous tissue injury compresses Tavg down to 4 years, yielding a predicted lifespan of only 40 years. Massive cell fragments continuously stimulate sustained immune activation and autoantibody secretion; these immune manifestations are secondary outcomes rather than the initiating cause of the disease. Conventional immunosuppressive therapy only relieves secondary inflammatory symptoms and cannot restore damaged hematopoietic G₀ architecture, so it fails to lift the depressed Tavg value fundamentally. Targeted interventions repairing bone marrow stem cell function and replenishing functional platelets effectively slow pathological cell turnover, recover Tavg and extend predicted lifespan. This paper quantitatively translates the qualitative cellular pathological logic of SFL-CELL-02 into calculable lifespan loss, forming a complete chain from bone marrow G₀ structural defect to systemic aging shortening.
FOO SENG ANG (Sun,) studied this question.