Aims The C-reactive protein–albumin–lymphocyte (CALLY) index is a composite biomarker reflecting inflammation, nutritional status, and immune response. This study evaluated the association of the CALLY index with all-cause mortality in patients undergoing transcatheter aortic valve implantation (TAVI).Methods In this retrospective study, 733 consecutive TAVI patients were classified as Low-CALLY (≤0.95) or High-CALLY (>0.95) using an ROC-derived cutoff. The primary endpoint was all-cause mortality during follow-up. Predictors of mortality were assessed using Cox proportional hazards regression, while discriminative performance and survival were evaluated by ROC and Kaplan–Meier analyses.Results Mortality was higher in the Low-CALLY group than in the High-CALLY group (57.1% vs. 19.3%; p < 0.001). The CALLY index showed moderate discrimination for mortality (AUC 0.719; 95% CI 0.681–0.757; p < 0.001). In multivariable Cox regression, Low CALLY remained independently associated with mortality in the clinical model (HR 3.31; 95% CI 2.49–4.39), STS-PROM-adjusted model (HR 3.16; 95% CI 2.37–4.22), and EuroSCORE II-adjusted model (HR 3.72; 95% CI 2.84–4.88) (all p < 0.001). Kaplan–Meier analysis showed lower survival in the Low-CALLY group (log-rank p < 0.001).Conclusion The CALLY index was independently associated with mortality after TAVI and may complement established risk scores in pre-procedural risk stratification.
Aslan et al. (Tue,) studied this question.