Higher serum uric acid levels were significantly associated with true severe low-flow, low-gradient aortic stenosis (6.77 vs. 5.08 mg/dL, p<0.001; AUC 0.823).
Observational (n=85)
Is serum uric acid associated with CT-derived aortic valve calcification in patients with low-flow, low-gradient aortic stenosis with reduced ejection fraction?
Serum uric acid levels are independently associated with CT-derived aortic valve calcification and may help identify true severe low-flow, low-gradient aortic stenosis.
Effect estimate: AUC 0.823
p-value: p=<0.001
Background: Low-flow, low-gradient aortic stenosis with reduced left ventricular ejection fraction is a heterogeneous condition with challenging severity assessment. Aortic valve calcification reflects fibro-calcific remodeling, while oxidative stress plays a key role in its pathogenesis. Serum uric acid, a marker of oxidative stress, may be associated with valvular calcification. This study investigated the relationship between serum uric acid levels and aortic valve calcification in this population. Methods: This retrospective study included 85 patients. Aortic valve calcification was quantified using computed tomography with the Agatston method, and patients were categorized as true severe or pseudo-severe according to sex-specific calcium thresholds. Of the patients, 57 were classified as true severe and 28 as pseudo-severe aortic stenosis. Results: Patients with higher calcification burden had significantly elevated serum uric acid levels (6.77 ± 1.57 vs. 5.08 ± 1.10 mg/dL, p < 0.001). Serum uric acid showed a modest correlation with aortic valve calcium score (ρ = 0.339, p = 0.002) and remained independently associated with CT-defined true severe low-flow, low-gradient aortic stenosis in multivariable analysis. ROC analysis yielded an area under the curve of 0.823 and identified a serum uric acid threshold of 5.45 mg/dL associated with a greater likelihood of CT-defined true severe low-flow, low-gradient aortic stenosis. Conclusions: Serum uric acid is associated with CT-derived aortic valve calcification and may provide insight into underlying fibro-calcific remodeling in this population.
Avcı et al. (Tue,) conducted a observational in Low-flow, low-gradient aortic stenosis with reduced ejection fraction (n=85). Serum uric acid vs. Lower serum uric acid levels was evaluated on CT-defined true severe low-flow, low-gradient aortic stenosis (AUC 0.823, p=<0.001). Higher serum uric acid levels were significantly associated with true severe low-flow, low-gradient aortic stenosis (6.77 vs. 5.08 mg/dL, p<0.001; AUC 0.823).