What question did this study set out to answer?

To discuss a rare case of an androgen-secreting steroid cell tumor presenting with postmenopausal bleeding and symptoms of hyperandrogenism.

June 26, 2026Open Access

Steroid Cell Tumor of the Ovary Presenting With Postmenopausal Bleeding and Hyperandrogenism: A Case Report

Key Points

To discuss a rare case of an androgen-secreting steroid cell tumor presenting with postmenopausal bleeding and symptoms of hyperandrogenism.
Reported a 60-year-old woman who experienced postmenopausal bleeding attributed to hormone replacement therapy.
Investigated persistent hirsutism and elevated serum testosterone with multidisciplinary team input.
Conducted bilateral salpingo-oophorectomy for definitive diagnosis.
Confirmed diagnosis of steroid cell tumor of the left ovary, FIGO stage IA.
Achieved complete biochemical and clinical resolution post-surgery.
Highlighted the need to reassess postmenopausal women presenting with hyperandrogenic symptoms.

Abstract

Steroid cell tumors of the ovary are rare, often hormonally active neoplasms that may present with features of hyperandrogenism. We report the case of a 60-year-old woman who initially presented with postmenopausal bleeding and a reassuringly thin endometrium, with symptoms attributed to hormone replacement therapy. Over time, the development of progressive hirsutism and persistently elevated serum testosterone levels prompted further investigation. Multidisciplinary team involvement, including endocrinology input, was pivotal in identifying a suspected androgen-secreting ovarian tumor and guiding definitive management. Bilateral salpingo-oophorectomy confirmed a steroid cell tumor of the left ovary, International Federation of Gynecology and Obstetrics (FIGO) stage IA, with complete biochemical and clinical resolution. This case highlights the importance of reassessing postmenopausal patients with evolving hyperandrogenic features despite initially reassuring findings.

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