Individuals with subclinical hypothyroidism and TSH <10 uIU/ml had significantly higher epicardial fat thickness compared to euthyroid controls (median 3.8 mm vs 2.6 mm; P=0.0002).
Cross-Sectional (n=70)
Is subclinical hypothyroidism with TSH <10 uIU/ml associated with increased epicardial fat thickness compared to euthyroid controls?
Subclinical hypothyroidism with TSH <10 uIU/ml is associated with increased epicardial fat thickness, suggesting elevated cardiovascular risk even in mild cases.
Absolute Event Rate: 3.8% vs 2.6%
p-value: p=0.0002
Abstract Introduction: Subclinical hypothyroidism is defined as a serum thyroid-stimulating hormone (TSH) level above the upper limit of normal despite normal levels of serum free thyroid hormones. While the cardiovascular risk in overt hypothyroidism is well established, the risk in subclinical hypothyroidism, especially those with TSH 5.33 to 4 mm). The receiver operating characteristic curve analysis showed that the discriminatory power of TSH (AUC 0.741; 95% confidence interval CI: 0.577 to 0.906) and LDL (AUC 0.752; 95% CI: 0.580 to 0.924) were acceptable to predict EFT >4 mm. Conclusion: Individuals with SCH exhibited significantly higher EFT compared to euthyroid controls, with a positive correlation observed between TSH levels and EFT.
Mohanty et al. (Fri,) conducted a cross-sectional in Subclinical hypothyroidism (n=70). Subclinical hypothyroidism (TSH <10 uIU/ml) vs. Age- and sex-matched controls was evaluated on Epicardial fat thickness (EFT) (p=0.0002). Individuals with subclinical hypothyroidism and TSH <10 uIU/ml had significantly higher epicardial fat thickness compared to euthyroid controls (median 3.8 mm vs 2.6 mm; P=0.0002).
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