Insomnia Symptoms and Psychopathology in Individuals at Clinical High Risk for Psychosis

ABSTRACT Aim Insomnia is common in the clinical course of schizophrenia, including in individuals at clinical high risk for psychosis (CHR‐P). We previously found associations between insomnia and psychosis‐risk symptoms in CHR‐P. We attempted to replicate findings in an independent cohort. Method We explored associations between insomnia and psychosis‐risk symptoms in CHR‐P individuals in the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program ( n = 269). We investigated relationships between insomnia and psychosis‐risk symptoms (Brief Psychiatric Rating Scale BPRS). Results The prevalence of any terminal and initial insomnia at AMP SCZ baseline was 28% and 38%, respectively. After controlling for potential confounders, insomnia was a significant indicator of higher BPRS total ( β = 0.33) and positive ( β = 0.22), affect ( β = 0.34), and activation ( β = 0.13) subscale scores. Discussion Insomnia is prevalent and associated with psychosis‐risk symptoms in CHR‐P individuals. Findings are clinically relevant and highlight the need for more rigorous assessment and treatment of insomnia in this population.