Abstract Background Legal frameworks governing identity are important determinants of population health, influencing Disability-Adjusted Life Years (DALYs) and progress towards the Sustainable Development Goals (SDGs). The Transgender Persons (Protection of Rights) Amendment Act, 2026 in India represents a shift from self-determined gender identity to a more regulated and medicalised framework. Methods This perspective paper presents a narrative public health analysis of the Transgender Persons (Protection of Rights) Amendment Act, 2026, drawing on published literature, policy documents and legal frameworks through a health systems and health equity lens. Results The amendment introduces additional medical and administrative verification processes, which may delay or obstruct access to gender-affirming healthcare. These barriers are likely to increase financial burden and contribute to unsafe or informal care pathways. The changes may worsen mental health outcomes, including depression, anxiety and suicidality, while also creating medico-legal uncertainty for healthcare providers. At a systems level, the amendment may reduce healthcare utilisation, increase mistrust in public institutions, contribute to data invisibility and exacerbate existing health inequities. Broader societal effects include reinforcement of stigma and disproportionate impact on socioeconomically marginalised populations. Conclusions The Amendment Act has significant implications for health equity and may undermine progress towards multiple Sustainable Development Goals, particularly those related to health, gender equality and reduced inequalities. Strengthening rights-affirming and inclusive legal frameworks is essential to reduce avoidable disease burden and DALYs associated with gender-based violence and structural exclusion.
D’Souza et al. (Sun,) studied this question.