The present studies are aimed to formulate and characterized emulgel of selected antifungal drugs luliconazole for the rapid easy onset of action in the treatment of acne vulgarises or skin disorder and to improve the bioavailability of the drug. Luliconazole being a BCS Class II drug has a low solubility and high permeability hence to increase the solubility of drug an emulgel was formulated which also ensures patient compliance. Formulation of better product than the currently marketed product, having better penetration and ultimately the efficacy of the final formulation when compared with marketed product. Hypothesis of Polymeric emulsifiers will be evaluated to convert unstable emulsion to a stable formulation with lower level of surfactant concentration. Formulation of emulgel with incorporation of maximum concentration of oil phase up to 50%w/w with lowest concentration of surfactants in aqueous phase can be done. The aim behind carrying out this research work is to formulate a stable emulgel of a hydrophobic drug Luliconazole of 1.0 % for the treatment of Fungal Infections which enhance the solubility and stability of Luliconazole.
Bhupendra Singh, Ajay Patel, Nilesh Gupta and Umesh Kumar Jain* (Wed,) studied this question.