What is the clinical evidence from this study?

Study design: Case Report. Population: Transthyretin cardiac amyloidosis (ATTR-CM) (n=2). Intervention: Tafamidis.

What question did this study set out to answer?

To explore instances of transthyretin cardiac amyloidosis in younger individuals, challenging existing age-related assumptions.

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July 9, 2026Open Access

Transthyretin cardiac amyloidosis beyond advanced age: two cases in unusually young patient

KBKrzysztof BaduraMedical University of Lodz ABAleksander Baszkowski MNMaciej NadelMedical University of Lodz

Key Result

Wild-type transthyretin cardiac amyloidosis can occur in unusually young patients in their early 50s, emphasizing the need to screen for red flags regardless of age to avoid delayed diagnosis.

Key Points

To explore instances of transthyretin cardiac amyloidosis in younger individuals, challenging existing age-related assumptions.
Case reports of two young patients diagnosed with transthyretin cardiac amyloidosis.
Clinical evaluations and diagnostic imaging were utilized to confirm the diagnosis.
Both patients exhibited significant cardiac dysfunction due to amyloidosis at a young age.
Findings highlight the importance of considering cardiac amyloidosis in younger demographics, leading to earlier diagnosis and management.

Study Design

Type

Case Report (n=2)

Structured PICO

Population

Two unusually young male patients, aged 51 and 56, who presented with heart failure and were diagnosed with wild-type transthyretin cardiac amyloidosis.

Reports two cases of transthyretin cardiac amyloidosis in unusually young patients.

Abstract

Polish Archives of Internal Medicine is an international, peer-reviewed, online-only periodical issued monthly in English as an official journal of the Polish Society of Internal Medicine. The journal is designed to publish articles related to all aspects of internal medicine, both clinical and basic science, provided they have practical implications.

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Cite This Study

Badura et al. (Mon,) conducted a case report in Transthyretin cardiac amyloidosis (ATTR-CM) (n=2). Tafamidis was evaluated. Wild-type transthyretin cardiac amyloidosis can occur in unusually young patients in their early 50s, emphasizing the need to screen for red flags regardless of age to avoid delayed diagnosis.

synapsesocial.com/papers/6a4f3b382b81a944af575339 https://doi.org/https://doi.org/10.20452/pamw.17340

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