Abstract Background: Modern neuroscience has described in detail the anatomical structures, neural circuits, and physiological mechanisms underlying visual function. However, considerably less attention has been devoted to the organizational principles through which these distributed mechanisms cooperate to preserve functional stability. Objective: To introduce the concept of Neurofunctional Stabilizers as the first organizational principle developed within the paradigm of Neurofunctional Integration and Visual Optimization (INOV), providing a conceptual framework for interpreting how multiple physiological mechanisms cooperate to maintain coherent visual function under continuously changing conditions. Methods: This work presents a conceptual analysis integrating established knowledge from systems neuroscience, ocular motor physiology, vestibular function, cerebellar physiology, proprioception, predictive processing, and adaptive neuroplasticity. Rather than proposing new anatomical structures or physiological pathways, the manuscript reorganizes existing evidence according to its contribution to functional stabilization. Results: Neurofunctional Stabilizers are defined as distributed physiological mechanisms whose coordinated activity preserves functional coherence across multiple levels of biological organization. Within the INOV paradigm, stability emerges from the continuous recruitment, interaction, and modulation of these mechanisms according to changing functional demands. Congenital strabismus is presented as a biological model through which these organizational principles become especially evident because developmental perturbation reveals adaptive stabilization processes that remain largely concealed under normal conditions. Conclusions: Neurofunctional Stabilizers constitute an organizational category that complements current neurophysiological knowledge by providing a unified conceptual language for studying biological stability. This framework generates testable hypotheses for future research in congenital strabismus, adaptive neuroplasticity, systems neuroscience, and the neuroeconomics of visual function.
Martín Gallegos‐Duarte (Tue,) studied this question.