[18F]FDG PET/CT incidentally detected a clinically silent myocardial metastasis in a 32-year-old man with cutaneous squamous cell carcinoma, leading to disease upstaging and palliative therapy.
Case Report (n=1)
Whole-body [18F]FDG PET/CT can incidentally detect rare, clinically silent myocardial metastases, significantly altering disease staging and management.
Myocardial metastasis from cutaneous squamous cell carcinoma (cSCC) is extremely rare and often clinically silent. We describe a 32-year-old man with recurrent invasive cSCC of the right lower limb who underwent contrast-enhanced 18 F-fluorodeoxyglucose positron emission tomography/computed tomography 18 FFDG PET/CT for systemic staging after multiple surgical resections and a hindquarter amputation. PET/CT showed intensely hypermetabolic lesions in the right inguinal region, left groin and lower abdominal wall, indicating active metastatic disease. Additionally, a focal hypermetabolic lesion (SUVmax 10.05), clearly exceeding physiological myocardial uptake, was found in the right ventricular apex with extension into the interventricular septum, suggesting myocardial metastasis. Transthoracic echocardiography later confirmed a corresponding intracardiac mass with preserved ventricular function. The patient was asymptomatic from a cardiac perspective. The detection of myocardial involvement resulted in disease upstaging and the start of systemic palliative therapy. This case emphasizes the importance of whole-body 18 FFDG PET/CT in uncovering rare and clinically hidden metastatic site that can significantly influence staging and treatment planning.
Akhter et al. (Wed,) conducted a case report in Cutaneous squamous cell carcinoma with myocardial metastasis (n=1). [18F]FDG PET/CT was evaluated on Detection of myocardial metastasis. [18F]FDG PET/CT incidentally detected a clinically silent myocardial metastasis in a 32-year-old man with cutaneous squamous cell carcinoma, leading to disease upstaging and palliative therapy.