What is the clinical evidence from this study?

Study design: Case Report. Population: Left atrial myxoma causing mechanical mitral prosthesis obstruction (n=1). Intervention: Surgical intervention.

What question did this study set out to answer?

To highlight a rare case of left atrial myxoma leading to obstruction of a mechanical mitral prosthesis.

July 18, 2026Open Access

Left atrial myxoma as an unusual cause of mechanical mitral prosthesis obstruction: a case report and literature review

RJRozita JalalianMazandaran University of Medical Sciences FMFatemeh MousaviMazandaran University of Medical Sciences FMFatemeh MousaviMazandaran University of Medical Sciences

Key Result

Surgical intervention successfully removed two sizable left atrial myxomas causing mechanical mitral prosthesis obstruction in a 43-year-old man.

Key Points

To highlight a rare case of left atrial myxoma leading to obstruction of a mechanical mitral prosthesis.
Detailed diagnostic imaging including CT scans to assess cardiac condition.
Surgical intervention to remove the identified masses.
Preoperative coronary angiography conducted to evaluate coronary artery status.
Imaging revealed large, mobile masses near the mitral valve consistent with left atrial myxomas.
Surgical intervention identified two sizable tumoral masses attached to the left atrium.
Normal coronary arteries were confirmed through preoperative angiography.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 43-year-old man with a history of mitral and aortic valve replacements presenting with left atrial myxomas causing mechanical obstruction.

Intervention

Surgical intervention (removal of left atrial myxomas)

Left atrial myxoma is a rare but important differential diagnosis for mechanical mitral prosthesis obstruction, highlighting the need for multimodality imaging.

Abstract

This case study reports on a 43-year-old man with a history of mitral and aortic valve replacements, who presented with worsening dyspnea, palpitations, chest pain, and vertigo. Despite stable vital signs and fluoroscopy, imaging revealed large, mobile masses near the mitral valve, likely indicating left atrial myxomas causing mechanical obstruction. Urgent CT scans ruled out embolism, and surgical intervention was performed, revealing two sizable tumoral masses attached to the left atrium. Preoperative coronary angiography showed normal coronary arteries. This case underscores the importance of comprehensive diagnostic evaluation and a multidisciplinary approach in managing complex cardiac conditions, particularly in patients with previous valve replacements.

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