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The article addresses cross-talk between T-Ag presence and pRb family, p53, and p73 signaling in medulloblastoma.

July 31, 2026Journal of Cellular Biochemistry0 citations

EXPRESSION OF CONCERN: Cross‐Talk Between T‐Ag Presence and pRb Family and p53/p73 Signaling in Mouse and Human Medulloblastoma

Key Points

The article addresses cross-talk between T-Ag presence and pRb family, p53, and p73 signaling in medulloblastoma.
Article review based on concerns raised by a third party regarding figure integrity.
Investigation focused on loading controls in specific figures.
Authors acknowledged an error during figure preparation.
Investigators found identical α-tubulin panels across figures, but differing lamin A/C controls.
Authors were unable to provide original data due to the time elapsed since publication.
Editors deemed that conclusions were unaffected despite the identified inconsistencies.

Abstract

EXPRESSION OF CONCERN: V. Caracciolo, M. Macaluso, L. D'Agostino, M. Montanari, J. Scheff, K. Reiss, K. Khalili and A. Giordano, “Cross-Talk Between T-Ag Presence and pRb Family and p53/p73 Signaling in Mouse and Human Medulloblastoma,” Journal of Cellular Biochemistry 110, no. 1 (2010): 182–190, https://doi.org/10.1002/jcb.22525. This Expression of Concern is for the above article, published online on March 24, 2010, in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Lucie Kalvodova; and Wiley Periodicals LLC. The Expression of Concern has been agreed upon following concerns raised by a third party. An investigation identified inconsistencies in the loading controls presented in Figures 4B and 6B. While the α-tubulin panels are identical across both figures, the corresponding lamin A/C controls differ. The authors acknowledged the issue and indicated that the error occurred during figure preparation. However, due to the time elapsed since the publication, they were unable to provide any original data. Although the conclusions are considered unaffected, the editors have decided to issue an Expression of Concern to inform and alert readers.

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