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OBJECTIVE: assessing health-related quality of life (HRQL) in patients with rheumatoid arthritis (RA), before and after treatment with biological therapy. METHODS: a longitudinal study, conducted from November 2010 to September 2011, with implementation of the instruments HAQ II (health assessment questionnaire) and SF-36 (medical outcomes short-from health survey). Barlett test, Anova, Friedman and paired t-test were performed for multiple extracts. RESULTS: 30 patients were evaluated, mean age of 47.6 (SD: 12.25) years and prevalence of females (90%). The mean score of HAQ II before treatment was 1.97, with significant reduction of up to 1.23 after six months of biological therapy (p<0.01). Most of the SF-36 domains showed significant improvement after six months of treatment (p<0.01), highlighting the social aspects, pain, physical functioning, emotional issues, vitality and physical aspects. CONCLUSION: the use of biologic therapy in patients with RA refractory to standard therapies proved to be an important pharmacological strategy for improving HRQL.
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Amanda Figueiredo Barbosa Azevedo
Kátia Petribú
Moacir de Novaes Lima
Revista da Associação Médica Brasileira
Universidade de Pernambuco
Universidade Federal do Vale do São Francisco
Hospital Universitário Oswaldo Cruz
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Azevedo et al. (Wed,) studied this question.
www.synapsesocial.com/papers/6a0285eccab5b316e39e1ec2 — DOI: https://doi.org/10.1590/1806-9282.61.02.126