Introduction Historically, irritable bowel syndrome (IBS) has been classified as a functional disorder, diagnosed through symptom-based criteria and managed by a uniform algorithm. However, current research suggests IBS may represent a group of disorders, each with an organic basis, such as post-infectious changes to the intestinal tract, inflammation and immune activation, gut-brain axis dysfunction, bile acid dysregulation, or gut microbiome irregularities.
Saidara et al. (Mon,) studied this question.