The relationship between interleukin-22 and clinical characteristics of patients with inflammatory bowel disease is uncertain. We sought to determine whether plasma interleukin-22 concentrations are associated with disease activity in a large population of patients with inflammatory bowel disease. This was an observational study of patients with Crohn's disease or ulcerative colitis in the Study of a Prospective Adult Research Cohort with IBD (SPARC IBD) from the IBD Plexus registry of the Crohn's ulcerative colitis: 39.8% vs. 23.0%, P < 0.001). A multinomial logit model found approximately twice the odds of moderate/severe disease activity in those with high interleukin-22 versus low interleukin-22 (below lower limit of quantification). The strongest predictors of high interleukin-22 concentrations identified by a machine-learning algorithm were higher Short Crohn's Disease Activity Index score in patients with Crohn's disease and prescription of biologics in patients with ulcerative colitis. In summary, high interleukin-22 concentrations tended to be associated with higher disease activity in this large, real-world population of patients with inflammatory bowel disease.
Cabrera et al. (Tue,) studied this question.