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September 5, 2025Open Access

Late‐Onset Penile Fracture After Collagenase Clostridium histolyticum Treatment for Peyronie’s Disease in a 70‐Year‐Old Patient

Key Points

Late-onset penile fracture occurred 32 days after collagenase treatment for Peyronie’s disease.
Fractures generally happen within weeks of treatment; this case highlights risks may extend beyond the advised 4-week abstinence.
This report is only the third known instance of corporal rupture post-injection at this time period.
While risks typically decrease over time, complications such as penile fracture are still possible.

Abstract

Collagenase Clostridium histolyticum (CCH) injections are the gold standard for nonsurgical management of Peyronie’s disease. While generally well tolerated, penis fracture is a known complication. Cases typically occur during intercourse in the weeks following treatment. Because of this, patients are advised to abstain from sexual activity for 4 weeks postinjection. Here, we present a case of corporal rupture occurring 32 days after treatment. This is only the third reported case occurring 30 days after injection. While the risk of penis fracture likely decreases with time, these cases illustrate that the risk may extend beyond 4 weeks.

Late‐Onset Penile Fracture After Collagenase Clostridium histolyticum Treatment for Peyronie’s Disease in a 70‐Year‐Old Patient

Key Points

Abstract

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