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September 10, 2025Open Access

ETRAISI registry report: clinical characteristics and related factors of outcome in reperfusion-eligible AIS patients

MGMojdeh GhabaeeTehran University of Medical Sciences SESharareh EskandariehTehran University of Medical Sciences NINeda IzadiResearch Institute for Endocrine Sciences

Key Points

The most common stroke risk factors included hypertension (67%) and diabetes (34%), impacting treatment strategies.
The median door-to-needle time for thrombolysis was found to be approximately 65 minutes, highlighting treatment delays.
Multiple linear regression indicated that NIHSS at admission and age are significantly associated with functional outcomes.
Data from 115 enrolled patients reveal insights into acute stroke management and support future treatment optimization.

Abstract

Stroke remains a major cause of disability and mortality worldwide, requiring comprehensive data collection for better management strategies. The Endovascular Thrombolysis Registry in Acute Ischemic Stroke of Iran (ETRAISI) was established March 21, 2023, to systematically document stroke epidemiology, treatment approaches, and outcomes in Iran. This study presents an analysis of registry data, focusing on patient characteristics, treatment time scales, and functional outcomes. A total of 115 patients diagnosed with acute stroke were enrolled at ETRAISI between March 21, 2023, and March 19, 2024. Clinical and demographic data, including stroke subtype, risk factors, treatment modalities, and outcome measures, were collected. Treatment time scales, such as door-to-needle time (DTN) for thrombolysis and door-to-groin puncture time (DTP) for thrombectomy, were analyzed. Factors associated with National Institutes of Health Stroke Scale (NIHSS) at discharge were assessed using multiple linear regression. Among 313 patients admitted at hospital as possible acute ischemic stroke (AIS), a total of 158 patients' candidate for intra-venous thrombolysis (IVT) or mechanical thrombectomy (MT) within 6-hours of onset, 115 enrolled, 81 patients (70.4%) underwent IVT, 8 (7.0%) patients received MT, and 26 patients (22.6%) underwent bridging therapy. The most common stroke risk factors were hypertension in 77 patients (67.0%), followed by diabetes in 39 (33.9%), and ischemic heart disease in 33 patients (28.7%). The median (IQR) of DTN was 65 (48-84.5) minutes, while the median (IQR) of DTP was 109 (75–158) minutes. The most frequent stroke etiology was undetermined observed in 33% patients. Multiple linear regression identified National Institutes of Health Stroke Scale (NIHSS) at admission, age, diastolic blood pressure, and treatment related complication were significantly associated with functional outcomes (p < 0.05). This study reported stroke management and outcomes in Iran. Identifying treatment time tracker and outcome related factors may inform policy changes and improve acute stroke care in Iran and Other developing countries. Benchmarking these findings against international registries can guide targeted interventions for optimizing stroke treatment.

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