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September 10, 2025

ortho/meta/para-Methylacetylfentanyl-Induced Unique Interferences in Fentanyl Urine Drug Testing with Immunoassay and LC-MS/MS

Key Points

Fentanyl urine drug testing accuracy is significantly compromised by interferences from methylacetylfentanyl.
Immunoassay and LC-MS/MS methods showed different levels of sensitivity to these interferences.
The study analyzed urine samples, focusing on the implications for forensic toxicology practices.
These findings emphasize the need for improved testing protocols to accurately detect fentanyl analogs.

Abstract

Journal Article ortho/meta/para-Methylacetylfentanyl-Induced Unique Interferences in Fentanyl Urine Drug Testing with Immunoassay and LC-MS/MS Get access David A Barajas , David A Barajas U.S. Army Forensic Toxicology Drug Testing Laboratory, Fort George G. Meade, MD, United States Search for other works by this author on: Oxford Academic Google Scholar Heather C Noda Carter , Heather C Noda Carter U.S. Army Forensic Toxicology Drug Testing Laboratory, Fort George G. Meade, MD, United States Search for other works by this author on: Oxford Academic Google Scholar Michael R Tomedi , Michael R Tomedi U.S. Army Forensic Toxicology Drug Testing Laboratory, Fort George G. Meade, MD, United States Search for other works by this author on: Oxford Academic Google Scholar Gregory D Reynolds , Gregory D Reynolds U.S. Army Forensic Toxicology Drug Testing Laboratory, Fort George G. Meade, MD, United States Search for other works by this author on: Oxford Academic Google Scholar Hieu T Dinh , Hieu T Dinh U.S. Army Forensic Toxicology Drug Testing Laboratory, Fort George G. Meade, MD, United States Search for other works by this author on: Oxford Academic Google Scholar Marisol S Castaneto , Marisol S Castaneto U.S. Army Forensic Toxicology Drug Testing Laboratory, Fort George G. Meade, MD, United States Search for other works by this author on: Oxford Academic Google Scholar Pucheng Ke Pucheng Ke U.S. Army Forensic Toxicology Drug Testing Laboratory, Fort George G. Meade, MD, United States Address correspondence to this author at: U.S. Army Forensic Toxicology Drug Testing Laboratory, 2490 Wilson Street, Fort George G. Meade, MD 20755, United States. Tel 301-677-3807; e-mail email protected. Search for other works by this author on: Oxford Academic Google Scholar The Journal of Applied Laboratory Medicine, jfaf116, https://doi.org/10.1093/jalm/jfaf116 Published: 21 August 2025 Article history Received: 14 May 2025 Accepted: 28 July 2025 Published: 21 August 2025

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