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September 10, 2025

A Case of Acute‐Onset CIDP With Pleocytosis in Cerebrospinal Fluid Presenting With Recurrent Acute Limb Weakness

Key Points

Patients with cidp may present with acute limb weakness, and prompt diagnosis is vital for effective treatment.
Cerebrospinal fluid pleocytosis was observed, highlighting an unusual but significant symptom of acute-onset cidp.
Comprehensive electrophysiological studies confirmed the diagnosis, emphasizing their importance in neuropathy assessment.
Treatment with intravenous immunoglobulin led to functional improvement, indicating its effectiveness for cidp patients.

Abstract

ABSTRACT Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated peripheral neuropathy commonly defined by symmetric involvement of both proximal and distal muscles. This case report describes a rare presentation of acute‐onset CIDP in a 45‐year‐old woman with mixed connective tissue disease and myasthenia gravis. She experienced recurrent episodes of acute limb weakness along with cerebrospinal fluid pleocytosis. Comprehensive electrophysiological studies identified proximal amplitude reductions and temporal dispersion abnormalities, affirming the diagnosis of CIDP. Functional improvement was achieved with appropriate treatment including intravenous immunoglobulin.

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