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This is a Quantitative Study study.

September 17, 2025

Whole-brain deuterium metabolic imaging (DMI) at 7T for depression assessment: A preliminary study in healthy volunteers

Key Points

Preliminary results show successful implementation of deuterium metabolic imaging for depression assessment.
Glc and Glx concentrations were quantified in five healthy subjects, indicating effective data processing.
The study used a dual-tuned head coil to enhance imaging performance during DMI acquisitions.
Findings suggest that DMI at 7T may provide a new approach for analyzing depressive disorders.

Abstract

Motivation: To achieve whole brain deuterium metabolic imaging (DMI) at 7T for assessing depression. Goal(s): Evaluate 1H/2H dual-tuned head coil performance, implement and optimize the protocol and data processing pipeline in a healthy volunteer study. Approach: Series DMI acquisitions were performed from the baseline (no glucose) to one hour after glucose administration; Glc and Glx concentration was quantified based on natural abundance 2H water. Results: Glc and Glx concentration qualification was achieved in five healthy subjects (one with a repeated scan). Impact: Preliminary results demonstrated the workflow of employing DMI at 7T to analyze patients with depressive disorders.

Whole-brain deuterium metabolic imaging (DMI) at 7T for depression assessment: A preliminary study in healthy volunteers

Key Points

Abstract

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