What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Technical Development and In Silico Implementation of SyntheticMR in Adaptive Radiation Therapy on the 1.5T MR-Linac

Key Points

SyntheticMR showed no significant geometric distortion, enhancing the precision of imaging used in radiation therapy.
The mean bias for T1 and T2 measurements was well within acceptable limits, enhancing treatment accuracy.
Analysis involved scanning phantoms and a volunteer, with results indicating high repeatability and reproducibility.
Implementation of syntheticmr can streamline the MR-Linac workflow, offering improved imaging information in a single scan.

Abstract

Motivation: SyntheticMR has not been studied on the 1.5T MR-Linac despite its potential value for treatment adaptation based on quantitative imaging. Goal(s): The goal of this study was to investigate the technical feasibility of translating SyntheticMR to the 1.5T MR-Linac for the radiation therapy workflow. Approach: SyntheticMR was scanned on phantoms and a volunteer and analyzed for geometric distortion and quantitative T1, T2, and PD vial measurements against reference values. Results: There was no significant geometric distortion. Mean bias was below 3% for T1, 13% for T2, and 3% for PD vials and the Lin's Concordance Correlation Coefficient was above 0.96 across all vials. Impact: SyntheticMR can enhance the MR-Linac workflow in the following ways: 1) multi-contrast anatomic/quantitative information in a single scan, 2) superior quantitative accuracy and spatial resolution compared to existing techniques, and 3) clinically acceptable repeatability, reproducibility, and spatial accuracy.

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