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September 17, 2025

The evaluation of MR staging of rectal cancer by using amide proton transfer weighted (APTw) imaging

Key Points

APTw imaging improves the accuracy of T staging in rectal cancer, achieving 76% compared to 45% without APTw.
Statistical analysis revealed significant accuracy improvement for T2 staging with a Z value of -2.51 (P=0.028).
Radiologists assessed T stage using MR images with APTw against pathological results as a reference standard.
The results suggest a better diagnostic approach for rectal cancer staging that could impact clinical practices.

Abstract

Motivation: Tumor staging is crucial for rectal cancer. Goal(s): To investigate the value of APTw imaging for rectal cancer staging. Approach: Both patients with confirmed rectal cancer and healthy volunteers as control group were included for MR scanning including APTw. Radiologists gave the T stage based on MR images with and without APTw. Statistical analyses were conducted to evaluate the diagnostical accuracy with pathological results as reference. Results: The accuracy of T staging with and without APTw on all cases with rectal cancer (n=50) was 76% and 45%, respectively. The statistical results of accuracy comparison showed significance for staging T2 (Z=-2.51, P=0.028<0.05). Impact: APTw imaging provides information on rectal cancer staging.

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