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September 17, 2025

Influence of Diffusion Time and Gradient Strength on the Estimation of Cell Size in MRI Cytometry

Key Points

Cell size estimation accuracy increases with gradient strength, and diffusion time plays a crucial role.
At 65mT/m, VERDICT significantly overestimated cell size compared to IMPULSED and OGSE methods.
Two animal tumor models were tested to analyze the impact of diffusion and gradient settings on cell size estimation.
Findings suggest incorporating OGSE into methods to improve accuracy in estimating tumor cell size.

Abstract

Motivation: To investigate the influence of diffusion time and gradient strength on the estimation of cell size in tumors in MRI cytometry. Goal(s): To find optimal diffusion time range and gradient strength to estimate tumor cell size. Approach: Two animal tumor models (B16 and MC38) were used. Cell size (d) was estimated utilizing VERDICT, IMPULSED and OGSE only methods at maximum gradient strengths. MRI-derived cell size was compared with histology ground truth. Results: VERDICT overestimated cell size compared to IMPULSED and OGSE only methods at gradient strength 65mT/m. Accuracy of cell size estimation increases with gradient strength but should cover broad diffusion time range. Impact: OGSE only and IMPULSED derived mean cell size were comparable at all gradient strengths while VERDICT overestimated the mean cell size at 65mT/m suggesting to include OGSE in estimating tumor cell size.

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