Abstract Background. Disparities in the incidence and overall survival (OS) from colon cancer (CC) between Black Americans (BA) and White Americans (WA) can be mitigated through navigated screening, improving outcomes for both races. The disparity exists from a variety of factors with the largest contribution from the economics associated with birth zip code. Subsequent biological consequences over a life’s period include alterations in gut microbiome and inflammation among other insults, setting up colonic stems cells to acquire somatic genetic changes that propel earlier and potentially more aggressive cancers. We have previously demonstrated elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) is associated with poor OS, with loss of heterozygosity (LOH) at the short arm of chromosome 9 (9p-LOH) improving OS of CC patients exhibiting EMAST. Here we examined for differences by race for 9p-LOH +/- EMAST. Materials 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr C111.
Koi et al. (Thu,) studied this question.