Background: Post-Traumatic Stress Disorder (PTSD) affects 8-10% of trauma-exposed individuals globally (2), with significant gender disparities in prevalence and clinical presentation. The relationship between PTSD and substance use disorders creates complex comorbidity patterns requiring gender-sensitive approaches. Objective: To examine gender-specific differences in PTSD symptom expression and addiction patterns among patients in addiction treatment settings. Methods: Cross-sectional epidemiological study with retrospective components examining 30 participants (60% women, 40% men) aged 18 and above with confirmed PTSD diagnoses and comorbid addictive disorders. Standardized questionnaires including PCL-5 assessments were combined with systematic medical record analysis over eight months. Statistical analyses employed Mann-Whitney U tests, Chi-square tests, and logistic regression models. Results: Women demonstrated higher PCL-5 total scores (56.3 vs 52.6) and greater intrusive symptoms (17.0 vs 14.8). Cannabis emerged as the primary self-medication substance (26.7% of sample), with 60% of users employing it for trauma-related symptoms. Women showed higher rates of cannabis use for trauma (70% of cannabis users), while men demonstrated greater stimulant use (70% of stimulant users). Psychiatric antecedents were prevalent (87%) with significant association to elevated PCL-5 scores (p < 0.05). Conclusions: Distinct gender-specific patterns emerged in trauma response and addiction behaviors. Women demonstrated internalized symptom presentations with higher intrusive symptoms, while men showed externalized patterns with greater symptom variability. These findings support the need for gender-sensitive screening and integrated treatment approaches in addiction settings. Keywords: PTSD, gender differences, addiction, self-medication, trauma, substance use disorders
Katir et al. (Sun,) studied this question.