Background: Benign prostatic enlargement (BPE) is frequently observed in aging men. An association exists between lower urinary tract symptoms (LUTS) and sexual dysfunction resulting from BPE. Objective: To compare the effect of Tamsulosin alone and Dutasteride in combination with Tamsulosin on men’s sexual function (ejaculatory function, libido) for managing LUTS secondary to BPE. Method: This quasi-experimental study was carried out at department of Urology, Nishtar Hospital Multan (2021-22) on 138 BPE patients in 2 equal groups. Group A was given Tamsulosin (0.4mg) and group B received combination of Tamsulosin and Dutasteride (0.4mg/0.5mg) at bedtime. Patients were followed in OPD at 3, 6, 9 and 12 months of study and each patient filled questionnaires on every visit of international prostate scoring system (IPSS), International Index of Erectile Function (IIEF-5) and Premature Ejaculation diagnostic tool (PEDT) to assess the sexual adverse effects. Data was analyzed in SPSS v25 using t-test for quantitative and chi-square for qualitative variables; p ? 0.05 was considered significant. Ethical approval was obtained from institutional committee. Results: Mean IPSS score in group A was 9.63±2.69 and in group B was 7.57±2.18 (p-value=<0.001). The mean Erectile dysfunction score in group A was 15.78±3.17 and in group B was 9.29±1.76 (p-value=<0.001). The mean ejaculation dysfunction score in group A was 8.92±2.19 and in group B was 12.39±2.02 (p-value=<0.001). Conclusion: While treating LUTS in patients with BPE, although combination therapy of Tamsulosin and Dutasteride is better, it has significant adverse effects on sexual activity compared to Tamsulosin monotherapy.
Hussain et al. (Tue,) studied this question.
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